Skin Repair：DEJ, Collagen, PIH
Structure and Matrix
Section titled “Structure and Matrix”Dermo-epidermal junction (DEJ, Basement membrane)
Section titled “Dermo-epidermal junction (DEJ, Basement membrane)”The junction structure between the epidermis and dermis. The “adhesion” discussed in acne-pockmark, laxity, and post-procedure repair contexts mostly refers to this.
Collagen (Collagen)
Section titled “Collagen (Collagen)”The main structural protein of the dermis. Type I provides support; type III is more involved in early repair and a finer network.
Elastic fiber (Fiber network)
Section titled “Elastic fiber (Fiber network)”The fiber network that provides recoil; with collagen, it determines firmness and contour.
Extracellular matrix (ECM, Structural scaffold)
Section titled “Extracellular matrix (ECM, Structural scaffold)”The filling and signaling environment composed of collagen, fibronectin, hyaluronic acid (HA), and others.
Laminin (Laminin)
Section titled “Laminin (Laminin)”An important glycoprotein component of the dermo-epidermal junction (DEJ), involved in anchoring and signaling.
Integrin (Adhesion receptor)
Section titled “Integrin (Adhesion receptor)”Matrix-adhesion receptors on the cell surface, related to ingredients such as palmitoyl tripeptide.
Fibroblast (Dermal cell)
Section titled “Fibroblast (Dermal cell)”Dermal cells that synthesize collagen and matrix; the direct target of collagen strategies.
Barrier and Pigmentation
Section titled “Barrier and Pigmentation”Tight junction (Barrier structure)
Section titled “Tight junction (Barrier structure)”An epithelial barrier structure, such as Claudin-1. Commonly used in intestinal-permeability and skin-barrier discussions.
Transepidermal water loss (TEWL, Barrier-function metric)
Section titled “Transepidermal water loss (TEWL, Barrier-function metric)”An indicator of barrier function; the higher it is, the more prone to dryness and sensitivity.
Post-inflammatory hyperpigmentation (PIH, Pigmentation)
Section titled “Post-inflammatory hyperpigmentation (PIH, Pigmentation)”Increased melanin after inflammation; common after acne, allergies, and cosmetic procedures.
Repair and Remodeling
Section titled “Repair and Remodeling”Actin (Cytoskeletal protein)
Section titled “Actin (Cytoskeletal protein)”A cytoskeletal protein that drives migration, related to repair research such as that on TB-500.
Angiogenesis (New blood-vessel formation)
Section titled “Angiogenesis (New blood-vessel formation)”The formation of new capillaries; the blood-supply bottleneck in tendon and wound repair.
Fibrosis (Disordered collagen deposition)
Section titled “Fibrosis (Disordered collagen deposition)”Disordered collagen deposition: scars harden, and tendons are “pasted over” rather than rebuilt in an organized way.
Scar adhesion (Abnormal collagen adhesion)
Section titled “Scar adhesion (Abnormal collagen adhesion)”Abnormal collagen adhesion between tissues; post-procedure pulling and restricted movement.
Read more: Signaling Pathways, Peptides and Formulation
Read more: Skin Barrier, Collagen and Laxity, GHK-Cu, BPC-157.
Further Reading
Section titled “Further Reading”Skin Barrier, Collagen and Laxity, GHK-Cu (PMID: 42787770).
Frequently Asked Questions
Section titled “Frequently Asked Questions”How Does This Page Relate to the Entry Pages?
Section titled “How Does This Page Relate to the Entry Pages?”This page covers mechanisms and terminology; for specific specifications, see Ingredient Entries.
Comparison Table
Section titled “Comparison Table”| Item | Description |
|---|---|
| Mechanism | See above |
| Entries | See blends |
| References | See individual ingredient entries |
Methods and References
Section titled “Methods and References”Skin barrier and TEWL measurements commonly use a Tewameter; PIH assessment includes colorimetry. Terminology definitions follow common usage in dermatological and cosmetic science; for mechanism texts see Skin Barrier, Collagen.
Safety Boundaries and Limitations
Section titled “Safety Boundaries and Limitations”This glossary is a terminology reference; it does not define indications or concentrations. The same INCI name performs differently in different formulation systems; when citing terms, cross-check the context and literature, and do not treat glossary entries as usage instructions.
Key Takeaways
Section titled “Key Takeaways”Core Mechanisms
Section titled “Core Mechanisms”First understand the pathway and the tissue/metabolic background, then cross-check ingredient entries and practical steps; avoid memorizing brand names alone.
Common Misconceptions
Section titled “Common Misconceptions”Treating a single ingredient as a complete protocol; ignoring underlying factors such as sleep, training, and diet; ignoring batch quality (COA).
Next Steps
Section titled “Next Steps”- Cross-check blends to select relevant mechanisms.
- When you need hands-on steps, see Reconstitution and Storage.
- For cross-page terminology, see the Glossary.
Term Quick Reference
Section titled “Term Quick Reference”| Term | What to watch | Extension |
|---|---|---|
| TEWL, Transepidermal water loss | Higher means drier and more reactive | Skin Barrier |
| PIH, Post-inflammatory hyperpigmentation | Increased melanin after inflammation | Pigmentation |
| DEJ, Dermo-epidermal junction | How well epidermis and dermis adhere | Atrophic Acne Scars |
| Fibrosis | Disordered collagen deposition | Scar Adhesion |
Related Reading
Section titled “Related Reading”- Term cross-checks: Signaling, Peptides and Formulation, Nutrient Terms.
- Ingredient entries: GHK-Cu, Topical Signal Peptides, Copper Peptides.
- Scenario entry points: Post-Laser, Dynamic Wrinkles, Collagen Laxity.